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Showing posts with label Mortality. Show all posts
Showing posts with label Mortality. Show all posts

Wednesday, May 23

UPSC GK: What is Nipah Virus and how to control it? (S&T)


Infection with the Nipah virus has killed at least 10 people out of 12 confirmed cases in Kozhikode and Malappuram of Kerala. While underlining the dangers of the disease, which has a high mortality rate, experts stress that there is no reason to panic because outbreaks, usually caused by fruit bats, have been generally localised. Teams rushed to Kerala by the Centre are working to contain the outbreak.

Containment is key
There is no need to panic, said Dr D T Mourya, director, National Institute of Virology (NIV). Virologists working on the ground say the outbreak has been localised and early diagnosis has helped contain the first wave. Although the outbreak has raised fears of travellers spreading the virus beyond Kerala, scientists have pointed out that it is a rare infection, traditionally localised.

Why localised
The reservoir for the virus is fruit bats, which roost on trees and rarely come into contact with humans. Less than 1% of bats will be infected with the virus and rarely will they infect humans, experts say. Bats can infect pigs, too, another way the disease can spread to humans. Infected humans can spread it to others they come in contact with. During a 1998-99 outbreak in Malaysia, Nipah virus antibodies were also detected in dogs, cats, goats and horses that had been exposed to infected pigs.

Containment vs treatment

Timely laboratory confirmation and aggressive epidemiologic tracing of contacts with patient quarantine and isolation can contain spread of the virus. This is important because there is no effective specific treatment for the infection. Treatment is symptomatic and supportive. Severely ill individuals need to be hospitalised and may require intensive care. Because Nipah virus encephalitis can be transmitted person-to-person, standard infection control practices and proper barrier nursing techniques are important.

High mortality
The disease has a very high mortality rate, which is the reason for the rush to contain it. In the previous two outbreaks in India, both in West Bengal, there were 42 deaths out of 72 cases in Siliguri in 2001, and five deaths out of 30 who showed the symptoms in Nadia in 2007.

Where it came from
Genetic studies on the Bengal outbreak suggested a relation to the Bangladesh strain of the virus. Consumption of raw date palm sap contaminated by bats was the primary source. Strong evidence indicated human-to-human transmission, Dr Mourya said.

How did the virus reach Kerala? “Extensive studies will be required at field and laboratory levels before we can make a comment,” an NIV scientist said. Human cases have been reported from only Bangladesh, India, Malaysia and Singapore; fruit bats are present in many other countries.

Danger signs
The classical form is an acute and rapidly progressive encephalitis with or without respiratory involvement. Nipah encephalitis comes with 3-14 days of fever and headache, followed by drowsiness, disorientation and mental confusion, Dr Mourya said. Acute encephalitis progresses to coma within 24-48 hours. Symptoms include non-productive cough during the early part of the disease.


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Sunday, October 9

End of Life: Ethical Dilemma


End of Life: Ethical Dilemma


UPSC General Studies: Paper IV

Question: Thanks to massive advance in medical science, we now live longer and better, but what do we do when the end comes? How to decide the fate of life?

Purpose of medical school was to teach how to save lives, not how to tend to their demise. But that’s what’s inevitably happening. How to take the crucial decision of pulling the plug? Should there be guidelines for de-escalating medical care?

Outline the ethical dilemmas involved. What can be done to address these dilemmas?

Backgrounder: Why we need to discuss these issues in India? (This is just for the sake of putting things in a perspective and not for the actual answer)

Problems of the elderly:

Medical science has ensured longer lives and India with its focus on its young “demographic dividend” will find that by 2050 its over-60 population will have increased from 8% of the population to 19%, finds a 2015 report by HelpAge India. Average life expectancy then will be 74 years.

At the same time, fertility rates will have declined from 5.9 children per woman at the time of Independence to 2.6 children per woman by 2050. What this simply will mean is more older people with fewer children to take care of them—and that’s just the impact on families without factoring in the implications on public healthcare that increased longevity will inevitably pose.

Pointers that will help tackle the above question:

Ethical dilemmas involved:

At what point do you tell the doctors that you cannot bear to hear the struggling breath of your mother?

How do you decide that it’s OK to feed her through a tube but not OK for doctors to cut a hole and insert a tube so that a ventilator can breath for her?

Home or hospital?

Dialysis or do nothing?

How do you decide the fate of a life? When that life belongs to a parent—ironically, the person who gave you life—the dilemma is unbearable.

Does wanting my mother to die quickly, unwilling to have her linger on and fade away make me a bad daughter or a son? What will the society think?

How to address these dilemmas?

Address the issue within lifetime within family: We have to tackle the issue of mortality during our lifetime. We all know that death is an inevitable finality. Yet, we are not at all open about discussing death within families. We need to have a discussion in advance. How do our parents want to die? In a hospital or at home? With the maximum medical intervention or the least? What about organ donation? But, he warns, this is a discussion for families to take at an appropriate time, when the going is good, not when confronted with a sudden decline in a parent’s health.

Have a relook at the laws: Laws are not supportive of end of life either. For instance, once a patient is on a ventilator then it cannot be withdrawn in the hospital without a court order that must be approved by a three-member committee.


Doctor’s must have guidelines as to how to respond in various emergencies: In an emergency, there is an implicit consent that you have to do everything to save the life of the patient, which could mean even attempting a heroic surgery on a 75-year-old stroke patient. Doctors don’t have guidelines on when to de-escalate care. There are so many grey areas. Address these grey areas.